{"id":19230,"date":"2026-08-05T16:36:38","date_gmt":"2026-08-05T07:36:38","guid":{"rendered":"https:\/\/www.nsg.gr.jp\/blog\/?p=19230"},"modified":"2026-08-05T16:46:48","modified_gmt":"2026-08-05T07:46:48","slug":"nuhw-driver-genes-202608","status":"publish","type":"post","link":"https:\/\/www.nsg.gr.jp\/blog\/nuhw-driver-genes-202608\/","title":{"rendered":"\u3010\u65b0\u6f5f\u533b\u7642\u798f\u7949\u5927\u5b66\u3011\u304c\u3093\u30c9\u30e9\u30a4\u30d0\u30fc\u907a\u4f1d\u5b50\u7570\u5e38\u306e\u591a\u304f\u306f\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u91cf\u3078\u306e\u5f71\u97ff\u304c\u9650\u5b9a\u7684"},"content":{"rendered":"

\u65b0\u6f5f\u533b\u7642\u798f\u7949\u5927\u5b66\u533b\u7642\u60c5\u5831\u7d4c\u55b6\u5b66\u90e8\u5065\u5eb7\u30c7\u30fc\u30bf\u30b5\u30a4\u30a8\u30f3\u30b9\u5b66\u79d1\u306e\u4e2d\u91ce\u6c38\u8b1b\u5e2b\u306f\u3001\u30d0\u30a4\u30aa\u30a4\u30f3\u30d5\u30a9\u30de\u30c6\u30a3\u30af\u30b9\u3092\u7528\u3044\u30667\u7a2e\u985e\u306e\u304c\u3093\u30fb754\u75c7\u4f8b\u306e\u30de\u30eb\u30c1\u30aa\u30df\u30af\u30b9\u30c7\u30fc\u30bf\u3092\u7d71\u5408\u89e3\u6790\u3057\u3001\u304c\u3093\u306e\u30c9\u30e9\u30a4\u30d0\u30fc\u907a\u4f1d\u5b50\u7570\u5e38\u306e\u5f71\u97ff\u304cmRNA\u767a\u73fe\u3092\u7d4c\u3066\u30bf\u30f3\u30d1\u30af\u8cea\u91cf\u307e\u3067\u3069\u306e\u7a0b\u5ea6\u4fdd\u305f\u308c\u308b\u306e\u304b\u3092\u5b9a\u91cf\u7684\u306b\u8a55\u4fa1\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u591a\u304f\u306e\u30c9\u30e9\u30a4\u30d0\u30fc\u907a\u4f1d\u5b50\u7570\u5e38\u3067\u306f\u3001\u305d\u306e\u5f71\u97ff\u304c\u30bf\u30f3\u30d1\u30af\u8cea\u91cf\u307e\u3067\u4e00\u8cab\u3057\u3066\u5f37\u304f\u4f1d\u308f\u308b\u3068\u306f\u9650\u3089\u306a\u3044\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u672c\u7814\u7a76\u6210\u679c\u306f\u3001\u56fd\u969b\u5bfe\u304c\u3093\u9023\u5408\uff08UICC\uff09\u306e\u516c\u5f0f\u5b66\u8853\u8a8cInternational Journal of Cancer\u306b2026\u5e747\u670816\u65e5\u4ed8\u3067\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/strong><\/span><\/p>\n

\u7814\u7a76\u306b\u3064\u3044\u3066<\/strong><\/span><\/h3>\n

\u3010\u7814\u7a76\u80cc\u666f\u3011<\/strong><\/span><\/p>\n

\u8fd1\u5e74\u3001\u304c\u3093\u6cbb\u7642\u3067\u306f\u60a3\u8005\u4e00\u4eba\u3072\u3068\u308a\u306e\u907a\u4f1d\u5b50\u5909\u7570\u306b\u5fdc\u3058\u3066\u6cbb\u7642\u85ac\u3092\u9078\u629e\u3059\u308b\u300c\u7cbe\u5bc6\u533b\u7642\u300d\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u4e00\u822c\u7684\u306b\u306f\u3001DNA\u306b\u751f\u3058\u305f\u907a\u4f1d\u5b50\u5909\u7570\u304cmRNA\u306e\u767a\u73fe\u5909\u5316\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u3055\u3089\u306b\u30bf\u30f3\u30d1\u30af\u8cea\u91cf\u3084\u7d30\u80de\u6a5f\u80fd\u306e\u5909\u5316\u306b\u3064\u306a\u304c\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u8003\u3048\u65b9\u306f\u3001\u73fe\u5728\u306e\u304c\u3093\u6cbb\u7642\u3084\u6cbb\u7642\u6a19\u7684\u306e\u9078\u629e\u3092\u652f\u3048\u308b\u91cd\u8981\u306a\u57fa\u76e4\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n

\u3057\u304b\u3057\u3001\u907a\u4f1d\u5b50\u5909\u7570\u306e\u5f71\u97ff\u304cDNA\u304b\u3089mRNA\u3001\u3055\u3089\u306b\u30bf\u30f3\u30d1\u30af\u8cea\u91cf\u3078\u3069\u306e\u7a0b\u5ea6\u4f1d\u308f\u308b\u306e\u304b\u306b\u3064\u3044\u3066\u306f\u3001\u3053\u308c\u307e\u3067\u5341\u5206\u306b\u5b9a\u91cf\u5316\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/span><\/p>\n

\u305d\u3053\u3067\u672c\u7814\u7a76\u3067\u306f\u3001Clinical Proteomic Tumor Analysis Consortium\uff08CPTAC\uff09\u304c\u516c\u958b\u3059\u308b7\u7a2e\u985e\u306e\u304c\u3093\u30fb754\u75c7\u4f8b\u306e\u30de\u30eb\u30c1\u30aa\u30df\u30af\u30b9\u30c7\u30fc\u30bf\u3092\u7528\u3044\u3066\u3001\u30b2\u30ce\u30e0\u3001mRNA\u767a\u73fe\u91cf\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u91cf\u3001\u30ea\u30f3\u9178\u5316\u30c7\u30fc\u30bf\u3092\u7d71\u5408\u89e3\u6790\u3057\u307e\u3057\u305f\u3002<\/span><\/p>\n

\"\u30c9\u30e9\u30a4\u30d0\u30fc\u907a\u4f1d\u5b50\u7570\u5e38\u304b\u3089mRNA\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u91cf\u3078\u306e\u60c5\u5831\u4f1d\u642c\u30b9\u30b3\u30a2\" \u30c9\u30e9\u30a4\u30d0\u30fc\u907a\u4f1d\u5b50\u7570\u5e38\u304b\u3089mRNA\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u91cf\u3078\u306e\u60c5\u5831\u4f1d\u642c\u30b9\u30b3\u30a2\uff08\u7834\u7dda\u306f\u5f37\u3044\u4f1d\u642c\u306e\u57fa\u6e96\u5024\u3092\u793a\u3059\uff09<\/span><\/p>\n

 <\/p>\n

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\u672c\u7814\u7a76\u3067\u306f\u3001\u30c9\u30e9\u30a4\u30d0\u30fc\u907a\u4f1d\u5b50\u7570\u5e38\u306e\u5f71\u97ff\u304cmRNA\u767a\u73fe\u3092\u7d4c\u3066\u3001\u3055\u3089\u306b\u30bf\u30f3\u30d1\u30af\u8cea\u91cf\u307e\u3067\u3069\u306e\u7a0b\u5ea6\u4fdd\u305f\u308c\u308b\u304b\u3092\u8a55\u4fa1\u3059\u308b\u72ec\u81ea\u306e\u89e3\u6790\u6307\u6a19\u3092\u69cb\u7bc9\u3057\u307e\u3057\u305f\u3002\u30d0\u30a4\u30aa\u30a4\u30f3\u30d5\u30a9\u30de\u30c6\u30a3\u30af\u30b9\u3068\u7d71\u8a08\u89e3\u6790\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u3001\u5206\u5b50\u60c5\u5831\u306e\u4f1d\u308f\u308a\u65b9\u3092\u5b9a\u91cf\u7684\u306b\u8a55\u4fa1\u3057\u307e\u3057\u305f\u3002<\/span><\/p>\n

 <\/p>\n

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\"\u7814\u7a76\u306e\u6d41\u308c:\u30d0\u30a4\u30aa\u30a4\u30f3\u30d5\u30a9\u30de\u30c6\u30a3\u30af\u30b9\u00d7\u30de\u30eb\u30c1\u30aa\u30df\u30af\u30b9\u89e3\u6790\"<\/span><\/p>\n

\u3010\u4e3b\u306a\u7d50\u679c3\uff1a\u7cbe\u5bc6\u533b\u7642\u306b\u304a\u3051\u308b\u30de\u30eb\u30c1\u30aa\u30df\u30af\u30b9\u8a55\u4fa1\u306e\u5fc5\u8981\u6027\u3092\u793a\u5506\u3011<\/strong><\/span><\/p>\n

\u672c\u7814\u7a76\u6210\u679c\u306f\u3001\u304c\u3093\u6cbb\u7642\u306e\u6a19\u7684\u3084\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3092\u8a55\u4fa1\u3059\u308b\u969b\u306b\u306f\u3001\u907a\u4f1d\u5b50\u5909\u7570\u3060\u3051\u3067\u5224\u65ad\u3059\u308b\u306e\u3067\u306f\u306a\u304f\u3001mRNA\u3084\u30bf\u30f3\u30d1\u30af\u8cea\u91cf\u3001\u30ea\u30f3\u9178\u5316\u306a\u3069\u3001\u8907\u6570\u306e\u5206\u5b50\u968e\u5c64\u306e\u60c5\u5831\u3092\u3042\u308f\u305b\u3066\u8a55\u4fa1\u3059\u308b\u5fc5\u8981\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n

\u672c\u7814\u7a76\u3067\u69cb\u7bc9\u3057\u305f\u89e3\u6790\u67a0\u7d44\u307f\u306f\u3001\u4eca\u5f8c\u3001\u72ec\u7acb\u3057\u305f\u30c7\u30fc\u30bf\u3084\u5b9f\u9a13\u7684\u691c\u8a3c\u3092\u91cd\u306d\u308b\u3053\u3068\u3067\u3001\u6cbb\u7642\u6a19\u7684\u3084\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306e\u6a5f\u80fd\u7684\u8a55\u4fa1\u3092\u88dc\u5b8c\u3059\u308b\u57fa\u76e4\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/span><\/p>\n

 <\/p>\n

\u3010\u7814\u7a76\u8005\u306e\u30b3\u30e1\u30f3\u30c8\u3011<\/strong><\/span><\/p>\n

\u304c\u3093\u306e\u907a\u4f1d\u5b50\u5909\u7570\u306f\u3001\u6cbb\u7642\u6a19\u7684\u3092\u9078\u629e\u3059\u308b\u91cd\u8981\u306a\u624b\u304c\u304b\u308a\u3067\u3059\u3002\u3057\u304b\u3057\u4eca\u56de\u306e\u7814\u7a76\u304b\u3089\u3001\u591a\u304f\u306e\u30c9\u30e9\u30a4\u30d0\u30fc\u907a\u4f1d\u5b50\u7570\u5e38\u3067\u306f\u3001\u305d\u306e\u5f71\u97ff\u304cmRNA\u3084\u30bf\u30f3\u30d1\u30af\u8cea\u91cf\u307e\u3067\u4e00\u8cab\u3057\u3066\u5f37\u304f\u4f1d\u308f\u308b\u308f\u3051\u3067\u306f\u306a\u3044\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u672c\u7814\u7a76\u3067\u306f\u3001\u30b2\u30ce\u30e0\u3001mRNA\u767a\u73fe\u91cf\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u91cf\u306a\u3069\u306e\u30de\u30eb\u30c1\u30aa\u30df\u30af\u30b9\u30c7\u30fc\u30bf\u3092\u7d71\u5408\u3057\u3001\u5206\u5b50\u60c5\u5831\u304c\u3069\u3053\u307e\u3067\u4f1d\u308f\u308b\u304b\u3092\u5b9a\u91cf\u7684\u306b\u8a55\u4fa1\u3057\u307e\u3057\u305f\u3002\u4eca\u5f8c\u306f\u3001\u907a\u4f1d\u5b50\u7570\u5e38\u306e\u5f71\u97ff\u304c\u3069\u306e\u5206\u5b50\u968e\u5c64\u3067\u5f31\u307e\u308a\u3001\u3042\u308b\u3044\u306f\u30bf\u30f3\u30d1\u30af\u8cea\u91cf\u306e\u5909\u5316\u3067\u306f\u306a\u304f\u3001\u6d3b\u6027\u3084\u4fee\u98fe\u306a\u3069\u306e\u5f62\u3067\u73fe\u308c\u308b\u306e\u304b\u3092\u660e\u3089\u304b\u306b\u3057\u3001\u6cbb\u7642\u6a19\u7684\u3084\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306e\u3088\u308a\u9069\u5207\u306a\u8a55\u4fa1\u306b\u3064\u306a\u3052\u305f\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n

 <\/p>\n

\u3010\u539f\u8ad6\u6587\u60c5\u5831\u3011<\/strong><\/span><\/p>\n

\u8ad6\u6587\u540d\uff1aPan-cancer quantification of driver alteration transmission across molecular layers reveals limited propagation to protein abundance<\/span><\/p>\n

\u8457\u8005\uff1aHisashi Nakano<\/span><\/p>\n

\u6240\u5c5e\uff1aDepartment of Health Data Science, Niigata University of Health and Welfare<\/span><\/p>\n

\u63b2\u8f09\u8a8c\uff1aInternational Journal of Cancer<\/span><\/p>\n

\u203b\u56fd\u969b\u5bfe\u304c\u3093\u9023\u5408\uff08UICC\uff1aUnion for International Cancer Control\uff09\u306e\u516c\u5f0f\u5b66\u8853\u8a8c<\/span><\/p>\n

\u51fa\u7248\u793e\uff1aWiley<\/span><\/p>\n

DOI\uff1a10.1002\/ijc.70657<\/span><\/p>\n

 <\/strong><\/span><\/p>\n

\u3010\u7814\u7a76\u8005\u60c5\u5831\u3011<\/strong><\/span><\/p>\n

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\u8b1b\u5e2b\u3000\u4e2d\u91ce\u3000\u6c38<\/span><\/p>\n

 <\/p>\n

\u3010\u65b0\u6f5f\u533b\u7642\u798f\u7949\u5927\u5b66\u3011\u3000https:\/\/www.nuhw.ac.jp\/<\/a><\/strong><\/span><\/p>\n

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